Ultrasound was not able to distinguish between hemorrhagic and ischemic lesions. Seizures are rare manifestation of thalamic disorder. The differential diagnoses of unilateral thalamic lesions include vascular lesions, mainly arterial thalamic infarctions , and tumors such as germinomas (14-17), gliomas , neurocytomas , and cavernous hemangiomas (20, 21). Unilateral anterior thalamic lesions produced evidence of a widespread hippocampal hypoactivity, as there were signi®cant reductions in Fos counts in a range of regions within the ipsilateral hippocampal formation (rostral CA1, rostral dentate gyrus, `dorsal' hippocampus, presubiculum and postsubiculum). Thalamic lesions are associated with possible neuro-ophthalmologic deficits that are important to distinguish from those caused by lesions in the midbrain or other locations. For patients with thalamic lesions, both bilateral T2*GRE and FLAIR lesions were more indicative of a lower GCS score than the corresponding unilateral lesions. During the study period, the incidence of unilateral thalamic lesions was 5.3 % among preterm infants. Fourteen We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. lesions were given either sham lesions or unilateral lesions of the posterodorsal amygdala (PDA) 20 days later. Hemiparesis, when present, was only a transient finding, whereas ataxia, dysmetria, dysdiadochokinesia, rebound, and hemisensory loss persisted. Natl. 49 Unilateral asterixis has been reported in patients with thalamic lesion; 50,51 uncommonly is related in lacunar infarction outset. Bilateral lesions of the thalamus, made within a relatively short time of each other, have a more profound and lasting effect than unilateral lesions. Seven patients had ischemic infarcts, and three had hemorrhages. USA 81, 4586-4590]. Fourteen patients with deep white matter lesions and 12 normal subjects served as controls. 2009 Oct;86(2-3):228-31. doi: 10.1016/j.eplepsyres.2009.05.017. The thalamus is affected in 1%-1.5% of brain tumors, including secondary involvement by contiguous spread of adjacent lesions such as pineal germ cell tumors. The lesions are T2/FLAIR hyperintense and T1 hypointense in the acute phase, often resolved after the acute phase. We performed extensive neuropsychological assessment of two male patients (matched for age and educational level) with similar (localization and size) unilateral paramedian ischemic thalamic lesions (AB on the left and SD on the right). Inability to stand in the absence of motor weakness or marked sensory loss is usually considered to reflect midline cerebellar disease. University-affiliated hospitals. BMC veterinary research. Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine BMC Vet Res. The aim of this study was to evaluate the differential effects of unilateral vestibular thalamic lesions on thalamo-cortical projections, right hemispheric dominance and reciprocal inhibitory . 1986; 142: 759-765. Both patients showed severe memory impairments as well as other cognitive deficits. Unilateral lesions were performed using ibotenic acid (0.2 μLof10μg ibotenic acid/μL in 0.01 M PBS) or saline [0.9% NaCl (vol/vol), 0.2 μL]. We report the case of a 48-year-old African-American woman who presented to our facility with vertical gaze palsy and evidence of left medial thalamic infarct on diffusion-weighted imaging without coexisting midbrain ischemia. 2013 Mar 27;9:59. doi: 10.1186/1746-6148-9-59. Of the unilateral lesions, 16 were left- and 12 right-sided paramedian lesions. Sixteen preterm infants, born after a gestational age of less than 35 weeks, with a unilateral thalamic lesion, but without additional significant cerebral . (J NeurolNeurosurgPsychiatry 1993;56:1224-1226) Hallucinations related to memory were reported in temporal lobe epilepsy and were In thalamic astasia a unilateral thalamic lesion causes postural instability or retropulsion or lateropulsion.1 In previous reports, the responsible lesions have been localized in the posterolateral thalamic area. He presented with fever and headache for two days before he sought medical . Unilateral thalamic lesions and generalized or lateralized spike wave discharges Epilepsy Res. The brain MRI revealed a lesion to the right thalamus which was isointense on TW1, hyperintense on TW2 and FLAIR, without enhancement on TW1 images (Figure 1). The aim of the study was to assess incidence, risk factors, clinical symptomatology and short-term outcome of unilateral thalamic lesions in preterm infants, as detected by ultrasound. Almost all of these lesions on histology prove to be gliomas but decompressive surgery is seldom feasible. In general, except for sensory deficits, unilateral thalamic lesions result in transient deficits. lesion.1-6 However, little is known about ipsilateral or bilateral ataxia induced by unilateral thalamic lesions. The infants with a unilateral thalamic lesion had a more complicated respiratory course and were ventilated significantly longer than infants without such a lesion. The thalamus is one of the frequent sites (together with the cerebellum, basal ganglia, cerebral white matter, hippocampus, and the corpus callosum) of extrapontine localisation. Neuropsychological deficits resulting from small, well demarcated, unilateral thalamic lesions were investigated in 13 right-handed patients. 2022 Sep 18. Sci. Patients with bilateral anteromedial thalamic degeneration Some authors state, however, that unilateral sleep spindle (fatal familial insomnia)3 and patients with bilateral para- absence is characteristic of an ipsilateral thalamic lesion6 median thalamic infarction show bilateral . There are three different clinical syndromes associated with lesions affecting the lateral thalamus. The exact location of the thalamic lesion was mentioned in 10 cases; the posterior or posterolateral thalamus was involved in six . types of unilateral thalamic lesions in humans is lacking. ventroposterior thalamic lesion primary somatosensory cortex activation cortical activation hand vibration somatosensory thalamic relay nucleus thalamic lesion unilateral thalamic lesion obvious neurological deficit regional cerebral blood flow healthy control selective hypoperfusion simple sensory stimulation vp lesion vp nucleus ipsilesional . The thalamus is surrounded by two thin layers of white matter. Whether only material-speci c memory de cits may occur as the result of unilateral lesions is debated. In this pilot study eight patients (five males, three females, mean age ± SD: 63.75±7.99 years) with unilateral thalamic infarction . Case reports. The other 16 patients all had a unilateral thalamic lesion with contralateral dystonia (10 hemidystonia, five focal dystonia affecting a hand and/or an arm, and one segmental dystonia involving face, arm, and hand). We report four adult patients who had thalamic lesions and lateralized or generalized spike wave discharges (SWDs). The clinical course of dAVFs with retrograde flows of intracranial veins shows a high risk of progressive neurological deficits and ultimately death. Acta Neurol Taiwan. Therefore, early intervention through endovascular treatment or surgical therapy is necessary. Dr. Joseph C. Masdeu MD, Corresponding Author . There has been speculation concerning the role that thalamic nuclei play in directing attention to locations in visual space [Crick, F. (1984) Proc. Medline Google Scholar MRI images of the thalamic lesion. Lesions of the thalamus and those extending into midbrain can cause various types of movement disorders such as dystonia, asterixis and ballism-chorea. Of the six rats excluded from the analyses, one sustained a large lesion that encroached into the lateral geniculate nucleus, one was found to have a tumor in the thalamus, apparently unrelated to the lesioning procedure, and four had incomplete or no lesions. Bilateral thalamic lesions are often associated with vascular causes, most commonly arterial occlusions (basilar artery, i.e., "top of the basilar syndrome") or deep venous occlusion. Initially, he went to a local hospital and was treated with Levofloxacin as a pneumonia infection. We hypothesized that the patients with unilateral thalamic lesions would demonstrate more impairment in both social cognitive and neurocognitive processes compared with healthy control group. Bilateral thalamic glioma is a rare neoplasm, usually a diffuse low-grade astrocytoma (World Health Organization grade II), that occurs in both children and adults [ 1 ]. On its superior surface, it is covered by the stratum zonale and on its lateral surface by the external medullary lamina. We tested basic olfactory functions, such as detection, as well as higher-order olfactory functioning, such . Bilateral Thalamic Lesions. During the study period, the incidence of unilateral thalamic lesions was 5.3% among preterm infants. Two 21-year . Authors Aude Castel 1 , Pierre Hélie, Francis Beaudry, Pascal Vachon. The aim of the study was to assess incidence, risk factors, clinical symptomatology and short-term outcome of unilateral thalamic lesions in preterm infants, as detected by ultrasound. The first one is characterised by hemisensory loss, hemiataxia, and involuntary movements. The differential diagnoses of unilateral thalamic lesions include vascular lesions, mainly arterial tha-lamic infarctions (3), and tumors such as germinomas (14-17), gliomas (18), neurocytomas (19), and cav-ernous hemangiomas (20, 21). Hemorrhage and contrast enhancement are rare. However, in rare cases, a unilateral thalamic . Patients with bilateral brainstem T2*GRE lesions had lower GCS scores compared with those with unilateral lesions, while this was less evident for FLAIR lesions. Since there were In: Nadjmi M. (eds) Imaging of Brain Metabolism Spine and Cord Interventional Neuroradiology Free Communications. [2][3][4] Although the majority of Japanese encephalitis had bilateral thalamic lesions, the unilateral lesion is uncommon. Haley Pysick, MD; Donn Dexter, MD; Christopher Lindsay, MD Verbal Amnesia Secondary to Unilateral Infarct of the Mediodorsal Thalamic Nucleus INTRODUCTION The thalamus is a component of the diencephalon involved in infor-mation processing, memory, attention, and executive function.1 The second and third ones include pure sensory and sensory-motor deficits, respectively [4]. Children typically have signs of increased intracranial pressure and movement disorders. In this study, the authors aimed to analyze the clinical, radiological, and pathological features of adult primary unilateral thalamus gliomas (UTGs).Clinical data of 33 UTGs in adults who underwent . Only Bassetti et al. It was con-cluded that a unilateral thalamic lesion could cause experiential hallucinations and the intralaminar and dorsomedial nuclei might be important structures to explainthephenomenon. Affiliation 1 Department of . Although vertical gaze palsy (VGP) is commonly associated with lesions of the rostral mesencephalon, there is some evidence that VGP may also be caused by a unilateral thalamic lesion. Neuropsychological deficits resulting from small, well demarcated, unilateral thalamic lesions were investigated in 13 right-handed patients. Ultrasound was not able to distinguish between hemorrhagic and ischemic lesions. In comparison to SD, AB showed severe impairment of executive functions and . Particular imaging techniques and attention to specific features may be Top of the basilar syndrome can be associated with bilateral or unilateral lesions. Authors F Irsel Tezer 1 , Serap Saygi. Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine BMC Vet Res. Discussion Holmes' tremor is an unusual delayed complication of various lesions in the upper brainstem 1 , 4 , 9-15 and thalamus. There are three different clinical syndromes associated with lesions affecting the lateral thalamus. Unilateral adult thalamic gliomas are rarely reported. thalamus were also affected. Particular imaging techniques and attention to specific features may be helpful in establishing the correct diagnosis. 21 ALFF mainly characterize the power of the low-frequency BOLD signal, which is supposed to indirectly reflect the extent or intensity of local intrinsic . Brainin M., Goldenberg G., Eisenstadter A., Neuhold A. The clinical expression may also depend on the age of the lesion. Brain Research, 292 (1984) 239-249 239 Elsevier Functional Consequences of Unilateral Lesion of the Locus Coeruleus: A Quantitative [14C]2-Deoxyglucose Investigation HELEN E. SAVAKI*, DAVID I. GRAHAM I, JOHN J. GROME and JAMES McCULLOCH Wellcome Surgical Institute and 1Department of Neuropathology , University of Glasgow, Glasgow ( U. K. ) (Accepted June 7th, 1983) Key words: glucose . 2013 Mar 27;9:59. doi: 10.1186/1746-6148-9-59. The role of the cortex and thalamus in the generation of SWDs is discussed. Read more related scholarly scientific articles and abstracts. Symmetrical bilateral involvement of the thalami has a broad differential diagnosis: vascular. 16-22 To our knowledge, ours is the first detailed description of a patient with Holmes' tremor subsequent to unilateral brainstem hemorrhage, whose severe tremor was markedly alleviated by bilateral Vim thalamic . The case of a 68-year-old man with persistent upward gaze palsy after a unilateral thalamic infarction, demonstrated on computed tomography and magnetic . Two patients had cerebellar outflow tremor. Fourteen rats sustained unilateral damage that included the visual sector of TRN. Bilateral lesions of homologous brain areas, in gen- eral, represent exceptional cases in topical diagnostics. It rarely is a consequence of unilateral thalamic infarction. We report new four adult patients with unilateral thalamic lesions that altered the integrity of the thalamocorticothalamic circuits. As the effects of an acute lesion recede, neglect may disappear, and inability to walk may yield to mild ataxia. Go to: Participants. The difference between our cases and those reported previously ( Inghilleri et al., 2002, Kelemen et al., 2006, Nguyen et al., 2006) was the presence of persistent and frequent lateralizing findings on EEG. Epub 2009 Jul 3. 16,18 Curiously, in our study, the classic characteristics of . While at least a part of the function of a brain area that has been affected by a. The involved, affected areas were centromedian nucleus of thalamus, lateral thalamic nuclei and red nucleus while the lesion seemed to extend to the upper brainstem. The performance of thalamic patients was generally worse than that of normals and In contrast to patients with pontomesencephalic lesions, patients with thalamic astasia did not exhibit the clinical signs of ocular tilt reaction.2 Furthermore, the assessment of . Upper row images illustrate the distribution patterns of thalamic strokes in axial (A) and coronal (B) slice in T1-weighted MNI standard space. Vertical gaze palsy is a recognized manifestation of midbrain lesions. a unilateral thalamic lesion may be treated with high doses of ketamine Aude Castel1, Pierre Hélie2, Francis Beaudry1 and Pascal Vachon1* Abstract Background: Central post-stroke pain is a neuropathic pain condition caused by a vascular lesion, of either ischemic or hemorrhagic origin, in the central nervous system and more precisely involving the
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unilateral thalamic lesions